理解早期乳癌复发的危险性

www.39.net  2007-05-29  www.webmd.com  

  也许你已经治疗早期乳腺癌,但是它会复发。诊断后的5年是它的高复发阶段,害怕它复发是非常正常的感觉,但是你可以用诊断报告来消除你的恐惧,对付住你的小心。尽可能多的学习对付复发可能的方法。

  复发的界定

  即使手术已经切除你的肿瘤,但是一些癌细胞可能还留在在你的身体中其他的地方。复发是一个描述癌症回归的一个术语,可以是发生在同一地点即原发肿瘤或是身体别的什么地方。乳癌能以下列的方式复发:

  局部复发:发生在乳腺癌开始,或在乳房皮肤深层组织来复发。即使你已经切除了乳房,这种情况仍然可能发生。区域性复发在受到影响的胸部附近的淋巴结中发生,这些地方的淋巴结包括手臂之下发现的淋巴结(腋窝的淋巴结),脖子、和在胸壁附近的淋巴结。

  远处复发:发生在身体的其他部位,如肺脏,肝脏,骨头或大脑。

  风险发生时间的推移

  下面的图表显示了乳腺癌复发情况,在10年内,每年乳腺癌早期诊断的病人得到任何辅助治疗(手术后治疗或无辐射) 所示的图表。

理解早期乳癌复发的危险性

  图中显示的是:初步诊断为乳癌而前三年内没有进行辅助治疗的病人,即使10年之后诊断还是出现一些复发迹象。

  更多的资料图表表示:

  这个表所获得的评估结果是来自55个临床试验,37000病例。结果来自不同的研究相结合,并评价,这样一来,它被称为“汇总分析”。临床试验包括汇总分析,开始于1990年之前,并且比较了含荷尔蒙辅助治疗的病人和未使用荷尔蒙辅助治疗的病人。Trialists的早期乳癌协同合作组(EBCTCG)对这55个试验进行的汇总分析。>>了解更多乳腺癌知识

原文:

Understanding risk of recurrence in early breast cancer
It's true that after you've been treated for early breast cancer, it can come back (recur). The highest risk of recurrence is within the first five years after diagnosis. It's perfectly normal to feel some fear about the possibility of recurrence. But you can fight fear with information. Get involved with your care. Learn as much as you can about recurrence and ways to reduce your risk.

Defining recurrence
Even though surgery has removed your tumor, it is possible that some cancer cells may remain elsewhere in your body. Recurrence is the term used to describe the return of cancer following initial treatment, either at the same site as the original tumor or somewhere else in the body. Breast cancer can recur in the following ways:

Local recurrence occurs in the breast where the cancer first started, or in the skin and underlying tissues where the breast used to be. This type of recurrence can happen even if you've had a mastectomy.
Regional recurrence occurs in the lymph nodes near the affected breast. These regional lymph nodes include nodes found under the arm (axillary nodes), in the neck, and in the chest wall.
Distant recurrence occurs in other parts of the body, such as the lung, liver, bone, or brain.

Risk of recurrence over time
The chart below shows the risk of breast cancer recurrence in each year during the 10-year period after a diagnosis of early breast cancer in patients who received no adjuvant treatment (treatment following surgery with or without radiation).

As indicated by the chart:

The risk of breast cancer recurrence without adjuvant treatment peaks within the first three years after an initial diagnosis of early breast cancer.
Some risk of recurrence was seen even 10 years following diagnosis.
More information about the chart above
This chart was obtained by evaluating results from a total of 55 clinical trials involving 37,000 patients. When results from different studies are combined and evaluated in this way, it is called a "meta-analysis."

Clinical trials included in this meta-analysis all began before 1990 and compared patients who took adjuvant hormonal treatment to patients who took no adjuvant hormonal treatment at all.
The Early Breast Cancer Trialists' Collaborative Group (EBCTCG) conducted the meta-analysis of these 55 trials.

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